Peritoneal Mesothelioma Patients Generally Present with Two Types of Symptoms
Another interesting study is called, "Expression of the secreted frizzled-related
protein gene family is downregulated in human Mesothelioma" by Amie Y Lee, Biao He, Liang You, Sina Dadfarmay, Zhidong Xu, Julien Mazieres, Iwao Mikami, Frank McCormick and David M Jablons - Oncogene (2004) 23, 66726676. Here is an excerpt: "Secreted frizzled-related proteins (sFRPs) comprise a family of five secreted glycoproteins that antagonize Wnt signaling. Aberrant activation and upregulation of the Wnt pathway is a key feature of many cancers. Thus, role of sFRP as a negative regulator of Wnt signaling may have important implications in tumorigenesis, and its downregulation has been correlated with human cancers. Recently, we reported Wnt signaling and dishevelled (Dvl) overexpression in malignant pleural mesothelioma (MM). Here, we report significant transcriptional downregulation of the SFRP gene family in MM primary tissues and cell lines as well as several other cancer cell lines (breast, lung, glioma, and cervical) compared to normal cells. One or more SFRPs were downregulated in approximately 85% (18 of 21) of primary MM tumor specimens compared to normal pleural tissue. Eight of the nine cancer cell lines we examined showed silencing of the SFRP family. Methylation-specific PCR (MSP) analysis showed that SFRP1, SFRP4, and SFRP5 gene promoters are frequently methylated in MM primary tissue (>80%). Furthermore, transfection of the SFRP gene construct into MM cell lines lacking SFRP expression resulted in apoptosis and growth suppression. Our results suggest that methylation silencing of SFRPs may be one of the important mechanisms of aberrant Wnt signaling activation in MM."
Another interesting study is called, "Diagnosis and treatment of peritoneal mesothelioma: The Washington Cancer Institute experience" by Paul H. Sugarbaker, Yair I.Z. Acherman, Santiago Gonzalez-Moreno, Gloria Ortega-Perez, O.Anthony Stuart, Pierre Marchettini, Dal Yoo - Volume 29, Issue 1, Pages 51-61 (February 2002). Here is an excerpt: "Abstract - Peritoneal mesothelioma is a rare disease, but increasing in frequency. The incidence is approximately one per 1,000,000 and about one fifth to one third of all mesotheliomas are peritoneal. Because of its unusual nature, the disease has not been clearly defined either in terms of its natural history, diagnosis, or management. This article reviews a single institution's experience with 51 patients prospectively treated over the past decade with increasingly aggressive local/regional protocols. Peritoneal mesothelioma patients generally present with two types of symptoms and signs; those with abdominal pain, usually localized and related to a dominant tumor mass with little or no ascites and those without abdominal pain, but with ascites and abdominal distention. Pathologically, a positive immunostain for calretinin has markedly increased the accuracy of diagnosis. Prognosis as determined by clinical presentation, the completeness of cytoreduction, and gender (females survive longer than males) appears to be improved by the use of intraperitoneal chemotherapy. Over the past decade, the management of these patients has evolved similarly to ovarian cancer treatment and now involves cytoreductive surgery, heated intraoperative intraperitoneal chemotherapy (HIIC) with cisplatin and doxorubicin, and early postoperative intraperitoneal paclitaxel. These perioperative treatments are followed by adjuvant intraperitoneal paclitaxel and second-look cytoreduction. Prolonged disease-free survival and reduced adverse symptoms with the current management strategy are documented by a high complete response rate as assessed by a negative second-look. This multimodality treatment approach with cytoreductive surgery and intraperitoneal chemotherapy has resulted in a median survival of 50 to 60 months. Peritoneal mesothelioma is an orphan disease that is treatable with expectations for "potential" cure in a small number of patients if diagnosed and treated early with definitive local/regional treatments. A prolonged high quality of life is possible in the majority of patients." Semin Oncol 29:51-61
Another interesting study is called, "Proteomic Analysis of Exosomes Secreted by Human Mesothelioma Cells" by Joost P.J.J. Hegmans, Martin P.L. Bard, Annabrita Hemmes, Theo M. Luider, Monique J. Kleijmeer, Jan-Bas Prins, Laurence Zitvogel, Sjaak A. Burgers, Henk C. Hoogsteden and Bart N. Lambrecht - American Journal of Pathology. 2004;164:1807-1815. Here is an excerpt: "Exosomes are small membrane vesicles secreted into the extracellular compartment by exocytosis. Tumor exosomes may be involved in the sampling of antigens to antigen presenting cells or as decoys allowing the tumor to escape immune-directed destruction. The proteins present in exosomes secreted by tumor cells have been poorly defined. This study describes the protein composition of mesothelioma cell-derived exosomes in more detail. After electrophoresis of exosome preparations, matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) was used to characterize the protein spots. MHC class I was found to be present together with the heat shock proteins HSC70 and HSP90. In addition, we found annexins and PV-1, proteins involved in membrane transport and function. Cytoskeleton proteins and their associated proteins ezrin, moesin, actinin-4, desmoplakin, and fascin were also detected. Besides the molecular motor kinesin-like protein, many enzymes were detected revealing the cytoplasmic orientation of exosomes. Most interesting was the detection of developmental endothelial locus-1 (DEL-1), which can act as a strong angiogenic factor and can increase the vascular development in the neighborhood of the tumor. In conclusion, mesothelioma cells release exosomes that express a discrete set of proteins involved in antigen presentation, signal transduction, migration, and adhesion. Exosomes may play an important role in the interaction between tumor cells and their environment."
We all owe a debt of gratitude to these fine researchers. If you found any of these excerpts interesting, please read the studies in their entirety.
Peritoneal Mesothelioma Patients Generally Present with Two Types of Symptoms
By: Montwrobleski77
Three Peritoneal and Three Pleural Mesotheliomas Mesothelioma and the Potential Accessibility of Tumors Mesothelioma and Neoadjuvant Chemotherapy Best Genital Warts Treatment - Apple Cider Vinegar, Garlic and Onion America Fighting Cancer' Group and Its Affect on People Get to Know the Best Known Treatment for Panic Attacks How Do You Stop The Panic? Treatment for Panic Attacks Natural Treatment for Panic Attacks What Is the Effective Treatment for Panic Attacks? Treatments to Help You in Overcoming Panic Options for Panic Disorder Treatment Panic Disorder Treatment Talking Therapy as a Panic Disorder Treatment