Apparent Diffusion In Microporous Membrane Flow Analysis Determination Of Bubble Point

Abstract: The micro-membrane filtration membrane bubble point analysis is a key technology areas

. In this paper, micro-membrane bubble point of the basic concepts, principles, and related analytical techniques were introduced, and proposed the concept of apparent diffusion flow. Concluded that the use of apparent diffusion flow analysis may be more in line with the objective of the bubble point of analysis.

Key words: membrane, apparent diffusion flow, bubble point

Biological pharmaceuticals, beverages, gas filtration and other fields, micro-filtration technology very widely [1,2]. Technological development in China in microfiltration, microfiltration membrane production, the filter manufacturing hundreds of business units. Microfiltration technology for different directions, the field is further broken down many more professional direction, the corresponding micro-filtration membrane products, filter products, filter performance requirements are very different, accordingly, different professional directions standard for the microfiltration membrane, filter quality control requirements are also different [3,4]. More prominent feature is the standard complex, difficult to achieve unity, the domestic MF industry is also a constraint.

Use in various applications in the pharmaceutical industry to filter biological agents with the most stringent requirements of [5]. In the pharmaceutical industry in accordance with the GMP requirements, terminal sterilization grade filter in the filter before and after filtration, are required for the integrity of testing, only through the filter integrity testing to ensure that the filtration efficiency of the process of sterilization filter . In general, Pharmacopoeia Require the use of measured bubble point, diffusion flow analysis method to meet the requirements of integrity testing sterilizing filters. Means confined to the limitations of the domestic bubble point for the analysis of the most basic standards, many practitioners or differences still exist between the enterprise standard. In this paper, the origin of the concept of bubble point and the associated principle of the development of automated machine analysis of a glimpse Discrepancy.

1. Bubble point basic concepts So-called bubble point, the most simple principle can be understood as such, take some membrane or filter materials with some wetting solution, and then put some pressure on the side of the gas pressure after isolation with the increase in gas pressure, gas released from the membrane side, the performance of the membrane at the side of size, ranging from the number of bubbles, the pressure value corresponding bubble point pressure. Experts have recommended further air bubbles can occur in the order and quantity, given bubble point pressure, bubble point pressure group, the whole bubble point pressure, a more specific definition. Therefore, the bubble point pressure broad understanding of the different may be replaced, respectively for the bubble point pressure and bubble point pressure group, the whole bubble point pressure.

Different understanding of why the above may be due to the flow of gas through membrane physical meaning there is no uniform understanding.

Bubble point pressure is completely wetting the membrane, pressure from the maximum aperture of a liquid gas pressure, the liquid used in experiments must be completely on the membrane wetting, when the hole in the membrane will filled with liquid. When the gas pressure is greater than the pore of membrane and surface tension of capillary pressure, the liquid film can be extrusion hole. If the type and wetting liquid film is different from that membrane material, membrane structure, pore size, surface tension and temperature changes will have an impact on the bubble point pressure. [6]

Filter is completely full after infiltration, the gas in the gas phase to adsorption, and plugging in the capillary wall in the liquid introduced to overcome some of the liquid surface tension, the tension and capillary pore physical properties, liquid - membrane material wetting angle and the gas pressure in the relationship are:

R = 2k cos / p Which: R?? Pore radius; ?? Liquid surface tension coefficient; ?? Liquid membrane material of the wetting angle;

p?? Gas hole on the role of the net in the capillary pressure;

K?? Hole correction factor.

Apparent Diffusion In Microporous Membrane Flow Analysis Determination Of Bubble Point

By: viedy

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