One interesting study is called, Proteoglycans in human malignant mesothelioma. Stimulation of their synthesis induced by epidermal, insulin and platelet-derived growth factors involves receptors with tyrosine kinase activity Biochimie Volume 81, Issue 7, July 1999, Pages 733-744 by Alexandra Syrokoua, George N. Tzanakakisb, Anders Hjerpeb and Nikos K. Karamanosa - Department of Chemistry, University of Patras, 261 10 Patras, Greece. Here is...more
One study is called, Immunohistochemical reactivity in mesothelioma and adenocarcinoma: A stepwise logistic regression analysis by Annika Dejmek, Anders Hjerpe - 1994 Acta Pathologica, Microbiologica et Immunologica Scandinavica APMIS Volume 102, Issue 1-6, pages 255264, January 1994. Here is an excerpt: Histological sections from 103 malignant mesotheliomas and 43 adenocarcinoma metastases in pleural biopsies were investigated for reactivity...more
One interesting study is called, Characterization of the IGF System and Analysis of the Possible Molecular Mechanisms Leading to IGF-II Overexpression in a Mesothelioma" by D. Hodzic, L. Delacroix, Ph. Willemsen, K. Bensbaho, J. Collette, R. Broux, P. Lefbvre, J. J. Legros, M. Grooteclaes, R. Winkler - Horm Metab Res 1997; 29(11): 549-555. Here is an excerpt: The expression of members of the IGF system in a mesothelioma from a patient suffering from hypoglycemia, in term placenta and HT29 colon adenocarcinoma cells were compared. Very high levels of IGF-II mRNA and protein were detected in the mesothelioma. Moreover, half of the IGF-II protein took the high-molecular-weight form. We also analyzed the parental imprinting status and the promoter usage of the IGF-II gene. Our results showed loss of imprinting (LOI) in the mesothelioma while the imprinting was maintained in HT29 cells, expressing moderate levels of the transcript. Promoter P4 was active in the three tissues we analyzed, whereas IGF-II mRNA transcription from promoter P3 was only detected in the mesothelioma and the placenta, expressing comparably high levels of the transcript. IGF-II gene structure was identical in...more
One interesting study is called, Impact of lymph node metastasis on outcome after extrapleural pneumonectomy for malignant pleural Mesothelioma by Marc de Perrot, MD, Karl Uy, MD, Masaki Anraku, MD, Ming S. Tsao, MD, Gail Darling, MD, Thomas K. Waddell, MD, Andrew F. Pierre, MD, Andrea Bezjak, MD, Shaf Keshavjee, MD, Michael R. Johnston, MD -...more
One interesting study is called, Absence of SV40 large T-antigen expression in human mesothelioma cell lines. By Pilatte Y, Vivo C, Renier A, Kheuang L, Greffard A, Jaurand MC - Am J Respir Cell Mol Biol. 2000 Dec;23 (6):788-93. - INSERM, Crteil, France. Here is an excerpt: Abstract - Simian virus (SV) 40 and SV40-like DNA sequences have recently...more
One interesting study is called, The histopathological diagnosis of malignant mesothelioma v. pulmonary adenocarcinoma: reproducibility of the histopathological diagnosis by B.G. Skov1,3,A.F. Lauritzen, F. Hirsch, H.W. Nielsen Histopathology - Volume 24, Issue 6, pages 553557, June 1994. Here is an excerpt: In a randomized design we examined the interobserver variation in the histopathological diagnosis of adenocarcinoma of the lung and malignant mesothelioma. In three rounds, three pathologists assessed slides from 42 tumours originally diagnosed as adenocarcinomas, malignant mesotheliomas or benign lesions in the pleura. In the first round the assessments were made on haematoxylin and eosin (H & E) stained sections; in the second, on H & E sections plus sections stained with histochemical mucin stains; and in the final round, the diagnoses were made on H & E sections and sections stained with a panel of antibodies against various antigens (cytokeratin, EMA, CEA, Ber-EP4, B72.3, Leu-M1, vimentin and S-100 protein) said to be of value in the differential diagnosis. The overall interobserver agreements for the three rounds were 0.659, 0.802 and 0.817; the kappa values were 0.461,...more
One interesting study is called, Adenovirus-mediated wild-type p53 overexpression reverts tumourigenicity of human mesothelioma cells. By Giuliano M, Catalano A, Strizzi L, Vianale G, Capogrossi M, Procopio A. Int J Mol Med. 2000 Jun;5(6):591-6. ...more
Orthotics: The Best Treatment Solution for Foot Disorders Nowadays lots of people complain about distinct kinds of pain due to the hectic daily routines that we have. With proper treatment, the impact that foot pain has on our day to day lives...more
I mentioned in the first video that I have been using Respen-A therapy for just about one year now in my practice. I am recording this particular video in October of 2010 and I plan on continuing to use Respen-A because I have found that it is quite...more
Vitiligo reasons and treatment method Vitiligo is actually a distinct type of leukodermal skin ailment. One among one hundred is noticed to be experiencing this skin ailment. De-pigmentation is the dominant attribute of Vitiligo. Individuals...more
If you are a sufferer of anxiety you will find there are many ways to treat it. Your best bet is to understand what type of anxiety you are dealing with and use the appropriate treatment for it. Whichever treatment you use you will have to monitor it...more
Toenail Treatments Are ImportantIf you have ever had a toenail that was infected by fungus then you know that sometimes it can seem like an impossible ailment to treat! Fungal infections are found underneath the toenail and because of that, they are...more