Inhibited Cell Growth and Asbestos Concentrations
Mesothelioma deaths among workers is a sad part of this country's history
. However, there is some important research being done regarding asbestos and its complications.
One interesting study is called, "Asbestos-induced sister chromatid exchanges in cultured Chinese hamster ovarian fibroblast cells." By Livingston GK, Rom WN, Morris MV. - J Environ Pathol Toxicol. 1980 Sep;4(2-3):373-82. Here is an excerpt: "Abstract - Asbestos fibers were tested for possible mutagenic activity using the Fluorescent Plus Giemsa (FPG) sister chromatid exchange (SCE) technique. Amosite, crocidolite, and chrysotile fibers were added to cell cultures at final concentrations of 10 and 100 micrograms/ml. Chrysotile completely inhibited cell growth at both concentrations; cells exposed to amosite and crocidolite proliferated but only at the lower concentration. Crocidolite significantly elevated the SCE rate and larger (greater than 5 mu) chromosomes were most sensitive. Amosite appeared to have a lesser effect on SCE frequency. Asbestos fibers are capable of disturbing cellular processes associated with chromosomal stability and effects vary with the asbestos type."
Another interesting study is called, "Mesothelioma among employees with likely contact with in-place asbestos-containing building materials." By Anderson HA, Hanrahan LP, Schirmer J, Higgins D, Sarow P. - Ann N Y Acad Sci. 1991 Dec 31. Here is an excerpt: "Abstract - The occurrence of mesothelioma is a sentinel event in occupational and environmental disease. A mesothelioma surveillance system was established utilizing existing computerized Wisconsin vital statistics data maintained since 1959 and a Cancer Reporting System (CRS) established in 1978. Review of the death certificate listing of usual occupation and industry from 487 mesothelioma deaths in Wisconsin from 1959 to 1989 led to the investigation of 41 persons with likely exposure to inplace asbestos-containing building materials (ACBM): 12 school teachers, 10 school maintenance employees, 7 public building maintenance workers, 5 private building maintenance workers, and 7 commercial and factory workers performing maintenance activities. For 10 (34%) of the 29 maintenance workers the only source of asbestos exposure identified was their maintenance work. For five (17%) histories indicated some prior employment in occupations and industries with probable asbestos exposures. Opportunities for indirect occupational exposure were identified for ten who had been employed in the residential construction industry. One maintenance worker was exposed to asbestos in the household and another had neighborhood exposure. For 9 (75%) of the school teachers, the only identifiable potential source of asbestos exposure was derived from in-place ACBM in schools. One teacher had spent a season in the merchant marine aboard an iron ore-hauling ship and 2 had worked in the residential construction industry. Two of the teachers were sisters, and in two instances, two teachers had taught in the same school facility. We conclude that individuals occupationally exposed to in-place ACBM are at risk for the subsequent development of mesothelioma."
Another interesting study is called, "Predictions of mortality from pleural mesothelioma in Italy: A model based on asbestos consumption figures supports results from age-period-cohort models" - International Journal of Cancer - Volume 115, Issue 1, pages 142147, 20 May 2005. Here is an excerpt: "Abstract - Italy was the second main asbestos producer in Europe, after the Soviet Union, until the end of the 1980s, and raw asbestos was imported on a large scale until 1992. The Italian pattern of asbestos consumption lags on average about 10 years behind the United States, Australia, the United Kingdom and the Nordic countries. Measures to reduce exposure were introduced in the mid-1970s in some workplaces. In 1986, limitations were imposed on the use of crocidolite and in 1992 asbestos was definitively banned. We have used primary pleural cancer mortality figures (19701999) to predict mortality from mesothelioma among Italian men in the next 30 years by age-cohort-period models and by a model based on asbestos consumption figures. The pleural cancer/mesothelioma ratio and mesothelioma misdiagnosis in the past were taken into account in the analysis. Estimated risks of birth cohorts born after 1945 decrease less quickly in Italy than in other Western countries. The findings predict a peak with about 800 mesothelioma annual deaths in the period 20122024. Results estimated using age-period-cohort models were similar to those obtained from the asbestos consumption model."
We all owe a debt of gratitude to these fine researchers for their important work. If you found any of these excerpts helpful, please read the studies in their entirety.
Inhibited Cell Growth and Asbestos Concentrations
By: Montwrobleski77
Sensitivity and specificity of the linkage procedure with occupational activity in asbestos production Per Capita Asbestos Consumption Rate and Mesothelioma Incidence Uptake of Long Asbestos Fibers by the Metaplastic Squamous Mucosa Asbestos Fibers Extracted From Lung and Counted Ceasured and Identified by Morphologic Examination Mesothelioma Arising in the Pleura in the Case of Peritoneal Mesothelioma T-suppressor Cells Significantly Elevated among Asbestos Workers Chrysotile Properties and the Mesothelioma Plague Attributable Risk and Exposure to Asbestos Inflammatory Disorders and the Increased Occurrence of Mesothelioma Fiber Analysis and the Asbestos Exposure Menace Marginal Increases in Mean Tail Moments and Mesothelioma Cells Evaluating Benign and Malignant Lung and Pleural Masses in Asbestosis and Mesothelioma Top Five Age Spot Removal Treatments