Indian Oncologists offer Sezary Syndrome Treatment in India at Incredible Success Rate

Indian Oncologists offer Sezary Syndrome Treatment in India at Incredible Success Rate

Advanced hospitals providing Sezary syndrome treatment in Indiaattracts patients from abroad and provide them with medical and esthetic care of their desire and enjoy the benefits of latest available technology and highly professional medical staff. Indian hospitals offer a premium service for patients wishing to benefit from the high quality of medicalservices as patients gain access to Indian medical expertise, superior healthcare and the latest medical technology. The complication rates of Sezary syndrome treatment in Indiaat international standard hospitals are very minimal.

What is Sezary syndrome?

Sezary syndrome is a type ofcutaneous T-cell lymphoma, characterized by skin abnormalities, extremeitching, enlarged lymphglands, and abnormal blood cells. Sezary syndrome is a type oflymphoma, which is a disease wherelymphocytes(a type of white blood cell) increase to very large numbers in a person's blood. Sezary syndrome is a type of lymphoma known as a cutaneous T-cell lymphoma, meaning that it is a disease where the white blood cells known as T-lymphocytes increase to large numbers. Sezary syndrome can affect many organs. In early stage disease, the skin is the only organ affected; however, later stage disease can affect other organ systems.

Causes and Symptoms of Sezary Syndrome

There are no known causes of Sezary syndrome. Early in the course of study of the syndrome, it was thought that exposure to certain chemicals could trigger the disease. However, later studies have not shown any relation between industrial chemical exposure and Sezary syndrome. The symptoms of Sezary syndrome can be very subtle; because of this, it is often not diagnosed for many years. Early symptoms includeskin lesionsthat can look likeeczemaandpsoriasis. Later symptoms can include skin tumors, especially in body folds. Enlarged lymph glands in the neck, armpits, andgroincan accompany the skin tumors. Later in the course of Sezary syndrome symptoms may relate to other areas of disease involvement.

Treatment of Sezary syndrome

Staging for cutaneous T-cell lymphoma, including Sezary syndrome, is based on the extent of skin involvement and the presence or absence of other manifestations of the syndrome. Stage I is characterized by mild skin involvement. In stage II there is extensive skin involvement, including skin tumors. Patients in stage III and IV have extensive skin involvement, blood abnormalities including Sezary cells, andswollenlymph nodes.

There are multiple therapies for Sezary syndrome. However, unless the disease is in an early stage, the chances for a complete cure are small. Nonspecific treatment includes skin lubricants and moisturizers to help treat the skinirritationand dryness that is common with the syndrome. Low potencysteroidcreams or ointments may be used to help treat itching and skin inflammation.

The first therapy used with some success against Sezary syndrome is mechlorethamine, or nitrogen mustard. It is applied daily to the entire skin surface (except for sensitive areas such as eyelids andgenitalia) for six to twelve months, then three times a week for one to two years more. Several studies have investiagted the effectiveness of nitrogenmustardtherapy, and have found that in stage I or II disease, the therapy causescomplete remissionin 6080% of patients. Side effects are minimal, but dry skin, irritation, and change in skinpigmentationcan occur.

Another treatment that has been used for many years, especially for stage II and III disease, is electron beamradiation therapy. Treatment with electron beam radiation therapy has been used since 1953, with good response rates seen in 5070% of patients. Side effects can include excessive skin dryness, skin blistering, loss of hair on treated areas, and increased risk of skin cancer.

ECP, orphotophoresis, has been approved as a treatment for Sezary syndrome. In this mode of treatment,phototherapywith ultraviolet light is combined with leukapheresis. In leukapheresis, a person's blood is taken out and passed through special filters that remove circulating Sezary cells; the cells are treated withultraviolet radiation, and then reinfused into the patient. Response rates range from 55% to 75%, with some reports showing a 1525% cure rate. Side effects can includenauseaandfever.

Systemicchemotherapyis often used in patients who are in later stages of the disease. Using standard cancer chemotherapeutic agents such ascyclophosphamide,vincristine, and doxorubicin, response rates up to 19 months have been seen. No studies have shown an increased survival rate in patients getting aggressive, high-dosechemotherapyversus those getting more standard doses.

The prognosis for patients with Sezary syndrome is based on placing the patient in one of three categories: good, intermediate, or poor. Patients with goodprognosishave the condition limited to their skin. Their general survival time is more than 10 years. Patients in the intermediate category have skin lesions including tumors and plaques, but no blood involvement. Their survival time is five years. Patients in the poor risk category have extensive skin lesions along with blood abnormalities, including high levels of Sezary cells. Patients in this category, even with extensive treatment, generally have survival rates of only one year or less.

Why consider India?

Advanced Hospitals of India offer the finest Sezary syndrome treatment and emergency medical care with ultra-modern surgical theaters and most advanced intensive care unit meeting the highest standards of safety and sterility and much more of the latest technologies. After ensuring a patient's acceptance into the most appropriate Indian hospital for theirmedicalprocedure, Medical tourism in India manages every detail to ensure their experience is safe and comfortable, with the highest standards of both medical and non-medical services.

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