Hemizygosity May Enhance Susceptibility To Asbestos Fibres
One interesting study is called, Hemizygosity of Nf2 is associated with increased
susceptibility to asbestos-induced peritoneal tumours by Jocelyne Fleury-Feith, Cline Lecomte, Annie Renier, Mireille Matrat, Laurence Kheuang, Vincent Abramowski, Franoise Levy, Anne Janin, Marco Giovannini and Marie-Claude Jaurand - Oncogene (2003) 22, 37993805. Here is an excerpt: Abstract - Biallelic NF2 gene inactivation is frequently found in human malignant mesothelioma. In order to assess whether NF2 hemizygosity may enhance susceptibility to asbestos fibres, we investigated the Nf2 status in mesothelioma developed in mice presenting a heterozygous mutation of the Nf2 gene (Nf2KO3/+), after intraperitoneal inoculation of crocidolite fibres. Asbestos-exposed Nf2KO3/+ mice developed tumoural ascites and mesothelioma at a higher frequency than their wild-type (WT) counterparts (P amosite > crocidolite. All three asbestos types were more toxic to I-407 than to ARL-6 cells. Chrysotile, amosite, and crocidolite were also tested for inhibition of colony formation in cultures of mouse colon-derived epithelial-like (MCE-1) cells; these cells were more resistant than the I-407 cells to all three fiber types; although similar to the ARL-6 cells in sensitivity to chrysotile and amosite, the MCE-1 cells were more sensitive to crocidolite then the ARL-6 cells. Leaching of the three asbestos forms for 3 days in sterile deionized water did not appreciably affect the cytotoxicity of I-407 or ARL-6 cells. Leaching in hydrochloric acid, however, greatly decreased the cytotoxicity of chrysotile on these cells and particularly in cultures of ARL-6 cells slightly increased the cytotoxicity of amosite and crocidolite. Leaching in deionized water altered the composition of the asbestos as revealed by release of substantial levels of Mg2+ and Ca2+ into the leaching fluid. Greater titers of these ions were released during leaching in hydrochloric acid.
If you found any of these excerpts interesting, please read the studies in their entirety. We all owe a debt of gratitude to these researchers for their hard work.
by: Mont Wrobleski
Mesothelioma And The Binding Capacity And Cytotoxicity Of Tested Asbestos Mineral Fibres Increases In Asbestos In The Past Century Have Necessitated Intense Study Exposed Workers With Mesothelioma Can Have A Significantly Higher Content Of Asbestos Fibre In The L Naval Shipyard Workers Smoking And The Mesothelioma Plague Affects Us All Louisiana Asbestos Cement Workers And Mortality Rates What Precisely Is The Most Crucial 1st Measure In Obtaining Alcohol Rehab Treatment Hectic fever and Unani Treatment What Are The Most Popular Day Spa Treatments Chemicals In Water Supply Near Chicago Linked To Cancer Exciting Window Treatments With Etched Glass Window Film Treatment for You to Say Goodbye to Dark Eyes Circles Male Breast cancer causes and risk factors | Herbal ayurveda remedies with no side effects Cancer and The Myopic Vortex