Exposed Workers With Mesothelioma Can Have A Significantly Higher Content Of Asbestos Fibre In The L

One interesting study is called, Asbestos-induced lung inflammation by Marek Rola-Pleszczynski

, Sylvie Gouin and Raymond Bgin - Inflammation Volume 8, Number 1, 53-62. Here is an excerpt: Abstract - In a recently developed sheep model of progressive low-dose pulmonary exposure to asbestos, initial alveolar lymphocyte and macrophage activation was followed by pulmonary neutrophilia in higher-dose exposed animals. This was observed after 18 months of exposure to intratracheal instillations of asbestos fibers and coincided with progressive alveolitis and decreased lung compliance. Alveolar macrophages from those animals were found to produce a chemotactic factor which attracted in vitro peripheral blood neutrophils. It attracted neutrophils more efficiently from higher-exposure than lower-exposure animals. Supernatants of control macrophages exposed to asbestos in vitro were also chemotactic for PMN. Similarly, bronchoalveolar lavage fluids from the animals showed chemotactic activity for peripheral blood neutrophils. It is suggested that chronic exposure to asbestos activates alveolar macrophages to produce chemotactic factors which in turn attract neutrophils from the vascular compartment and may thus contribute to the inflammatory process in asbestosis.

Another interesting study is called, Mineral fibres, fibrosis, and asbestos bodies in lung tissue from deceased asbestos cement workers. By M Albin, L Johansson, F D Pooley, K Jakobsson, R Attewell, R Mitha - Br J Ind Med 1990;47:767-774. Here is an excerpt: Abstract - Lung tissue from 76 deceased asbestos cement workers (seven with mesothelioma) exposed to chrysotile asbestos and small amounts of amphiboles, has been studied by transmission electron microscopy, together with lung tissue from 96 controls. The exposed workers with mesothelioma had a significantly higher total content of asbestos fibre in the lungs than those without mesothelioma, who in turn, had higher concentrations than the controls (medians 189, 50, and 29 x 10(6) fibres/g (f/g]. Chrysotile was the major type of fibre. The differences were most pronounced for the amphibole fibres (62, 4.7, and 0.15 f/g), especially crocidolite (54, 1.8 and less than 0.001 f/g), but were evident also for tremolite (2.9, less than 0.001, and less than 0.001 f/g) and anthophyllite (1.7, less than 0.001, and less than 0.001 f/g). For amosite, there was no statistically significant difference between lungs from workers with and without mesothelioma; the lungs of workers had, however, higher concentrations than the controls. Strong correlations were found between duration of exposure and content of amphibole fibres in the lungs. Asbestos bodies, counted by light microscopy, were significantly correlated with the amphibole but not with the chrysotile contents. Fibrosis was correlated with the tremolite but not the chrysotile content in lungs from both exposed workers and controls. Overall, similar results were obtained using fibre counts and estimates of mass.

Another interesting study is called, Identification of a particular amphibole asbestos fiber in tissues of persons exposed to a high oral intake of the mineral by Robert E. Carter and William F. Taylor - Environmental Research - Volume 21, Issue 1, February 1980, Pages 85-93. Here is an excerpt: Abstract - Samples of liver, jejunum, and lung tissue from each of 32 persons with long-term, high-level oral exposure to a ferromagnesium silicate amphibole asbestos were ashed, and the residue was analyzed by means of transmission electron microscopy with selected area electron diffraction, and energy dispersive X-ray analytic techniques. Fibers of the type ingested were identified in the tissues of 29 of the 32 persons. Among 21 controls, the tissues of only 2 subjects contained this type of fiberin each, a single fiber from a single tissue specimen. Chrysotile asbestos fibers were found in all tissues in most of the subjects studied.

If you found any of these excerpts interesting, please read the studies in their entirety. We all owe a debt of gratitude to these researchers for their hard work.

by: Mont Wrobleski

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