Another interesting study is called, Modified RECIST criteria for assessment of response in malignant pleural Mesothelioma by M. J. Byrne and A. K. Nowak - Ann Oncol (2004) 15 (2): 257-260. Here is an excerpt: Abstract - Background: The growth pattern of malignant pleural mesothelioma makes the use of RECIST (response evaluation criteria in solid tumours) response criteria difficult. We have developed and validated Modified RECIST criteria...more
Another interesting study is called, Mesothelioma: profile of keratin proteins and carcinoembryonic antigen: an immunoperoxidase study of 20 cases and comparison with pulmonary adenocarcinomas. - Am J Pathol. 1982 July; 108(1): 8087 by J. M. Corson and G. S. Pinkus. Here is an excerpt: Abstract - The distribution of keratin proteins and carcinoembryonic antigen (CEA) in 20 diffuse pleural malignant mesotheliomas and 20 adenocarcinomas of the...more
Another interesting study is called, Value of the Mesothelium-Associated Antibodies Thrombomodulin, Cytokeratin 5/6, Calretinin, and CD44H in Distinguishing Epithelioid Pleural Mesothelioma from Adenocarcinoma Metastatic to the Pleura by P M Cury M.D., D N Butcher, C Fisher M.D., B Corrin M.D. and A G Nicholson D.M. - Mod Pathol 2000;13(2):107112. Here is an excerpt: Abstract - Until recently, the standard approach of most laboratories in distinguishing epithelioid pleural mesothelioma from metastatic adenocarcinoma has been a negative result from a panel of adeno-carcinoma-associated antibodies. However, several "mesothelium-associated" antibodies have been proposed as useful in this situation, and we have applied four of these putative mesothelioma markersthrombomodulin, cytokeratin 5/6, calretinin, and CD44Hto a series of 61 epithelioid pleural mesotheliomas and 63 metastatic adenocarcinomas with known primary sites (lung = 19; breast = 21; ovary = 6; colon = 10; kidney = 4; uterus, epididymis, pancreas = 1 case each). Of the mesotheliomas, 55 of 61 (90%) stained for thrombomodulin, 56 of 61 (92%) for cytokeratin 5/6, 47 of 51 cases (92%) were positive for calretinin, and 39 of...more
Another interesting study is called, Codeletion of p15 and p16 in primary malignant mesothelioma. By Xio S, Li D, Vijg J, Sugarbaker DJ, Corson JM, Fletcher JA. - Oncogene. 1995 Aug 3;11(3):511-5. Department of Pathology, Children's Hospital, Boston, Massachusetts. Here is an excerpt: Abstract - The p15 and p16 CDK4 inhibitor genes map within the...more
Another interesting study is called, Value of calretinin immunostaining in differentiating epithelial mesothelioma from lung adenocarcinoma. By Ordez NG. The University of Texas M.D. Anderson Cancer Center, Houston 77030 - Mod Pathol. 1998 Oct;11(10):929-33. Here is an excerpt: Abstract - Only recently have immunohistochemical markers been...more
Another interesting study is called, Neoadjuvant Chemotherapy Followed by Extrapleural Pneumonectomy in Malignant Pleural Mesothelioma by Walter Weder, Peter Kestenholz, Christian Taverna, Stefan Bodis, Didier Lardinois, Monika Jerman, Rolf A. Stahel - Journal of Clinical Oncology, Vol 22, No 17 (September 1), 2004: pp. 3451-3457. Here is an excerpt: PATIENTS AND METHODS: Eligible patients had MPM with clinical stage T1-3, N0-2, M0 disease considered to be completely resectable and a WHO performance status of 0 to 2. Neoadjuvant chemotherapy consisted of three cycles of cisplatin 80 mg/m2 on day 1 and gemcitabine 1,000 mg/m2 on days 1, 8, and 15, given every 28 days. Surgery had to consist of a complete extrapleural pneumonectomy, including resection of pericardium and diaphragm. Postoperative radiotherapy was to be considered for all patients. RESULTS: Nineteen patients with MPM were included in this pilot study. According to the European Organization for Research and Treatment of Cancer prognostic score, two patients were in the good prognosis group, and 17 patients were in the poor prognosis group. The response rate to neoadjuvant chemotherapy was 32%. The major toxicity was...more
An abdominal hernia occurs when either fatty tissue or an organ in the abdomen protrudes through a weak point or tear in the muscles or tissues around it. The protrusion can be labeled either as reducible, which means it can be pushed...more
American Cancer Treatment Organization is created in order to help people stay well or treat a persons problem. In majority of all cases people find themselves left alone and neglected by other individuals and the society as well. This is the main...more
Mobile phone deals are gaining popularity amongst the mobile lovers. These mobile phone deals have made it easier for the customer to get latest multifunctional handsets at pocket friendly rates. Previously it was a big problem for the...more
The effects of a migraine can be so severe, that some persons will do just about anything to get some relief. This relief can be in the form of medication or alternative treatments.Migraines have been attributed in part, to changes in the body...more
The severity of a migraine headache can sometimes cause so much pain that some people will go to great lengths just to get some relief. Migraines can be treated by the use of prescription medication which can be either abortive or preventive, non...more
Once considered the miracle mineral it is now known that inhaling asbestos fibers causes lung cancer, and other respiratory illnesses. Asbestos that is not damaged is not a health hazard. It is only when asbestos fibers are released into the air is a...more