One interesting study is called, "Determinants of restrictive lung function in asbestos-induced pleural fibrosis" by D. A. Schwartz, J. R. Galvin, C. S. Dayton, W. Stanford, J. A. Merchant and G. W. Hunninghake - Department of Internal Medicine, University of Iowa, Iowa City 52242. J Appl Physiol 68: 1932-1937, 1990. Here is an excerpt: "We evaluated whether restrictive lung function among asbestos-exposed individuals with pleural...more
One interesting study is called, "Hemizygosity of Nf2 is associated with increased susceptibility to asbestos-induced peritoneal tumours" by Jocelyne Fleury-Feith, Céline Lecomte, Annie Renier, Mireille Matrat, Laurence Kheuang, Vincent Abramowski, Françoise Levy, Anne Janin, Marco Giovannini and Marie-Claude Jaurand - Oncogene (2003) 22, 3799–3805. Here is an excerpt: "Abstract - Biallelic NF2 gene inactivation is...more
One interesting study is called, "In vitro approaches for determining mechanisms of toxicity and carcinogenicity by asbestos in the gastrointestinal and respiratory tracts." By B T Mossman - Environ Health Perspect. 1983 November; 53: 155–161. Here is an excerpt: "Abstract Organ and cell cultures of gastrointestinal and tracheobronchial epithelium have been used to document both the interaction of asbestos with mucosal cells and the sequence of cellular events occurring after exposure of cells to fibers. The biological activity of various types of asbestos in vitro is related to surface charge, crystallization, and dimensional characteristics. These factors also influence adsorption of natural secretions and serum components to fibers, a process that ameliorates cytotoxicity. Although mechanistic studies at the cellular level are lacking using epithelial cells of the digestive tract, asbestos appears to elicit a constellation of morphologic and biochemical changes in tracheal epithelium that resemble effects of classical tumor promoters on target cells."Another interesting study is called, "Binding of environmental carcinogens to asbestos and mineral fibres." By G...more
One interesting study is called, "A retrospective mortality cohort study of chrysotile asbestos products workers in Tianjin 1972–1987" by Wei-nan Cheng and Jian Kong - Environmental Research - Volume 59, Issue 1, October 1992, Pages 271-278. Here is an excerpt: "The mortality rate of a cohort of asbestos workers was investigated...more
One interesting study is called, "Asbestos-induced lung inflammation" by Marek Rola-Pleszczynski, Sylvie Gouin and Raymond Bégin - Inflammation Volume 8, Number 1, 53-62. Here is an excerpt: "Abstract - In a recently developed sheep model of progressive low-dose pulmonary exposure to asbestos, initial alveolar lymphocyte and...more
One interesting study is called, "Asbestos exposure enhances the release of fibroblast growth factor by sheep alveolar macrophages." By Lemaire I, Rola-Pleszczynski M, Bégin R. - J Reticuloendothel Soc. 1983 Apr;33(4):275-85. Here is an excerpt: "Abstract - Interaction between free airway cells (FAC) and lung fibroblasts was studied in a sheep model of asbestosis. Three groups of six sheep each received, respectively, by repeated intratracheal instillations, saline (control), 328 mg (low dose), and 2282 mg (high dose) of UICC chrysotile B asbestos. Sixteen months after the first instillation, FAC obtained by segmental bronchoalveolar lavage (BAL) of sheep in each group were incubated for various intervals, and the effect of their culture supernatants (FAC-SN) on human embryonic lung fibroblast proliferation was determined. FAC-SN from control animals stimulated thymidine (3H-TdR) incorporation by lung fibroblasts two- to threefold compared to untreated cultures. Maximal stimulation was observed at 48 hr and was correlated with a significant increase of the fibroblast population at 72 hr. FAC population from control sheep consisted primarily of macrophages (79%) and...more
One interesting study is called, "Histologic type of lung cancer and asbestos exposure" by Oscar Auerbach MD, Lawrence Garfinkel MA, Verta R. Parks BS, Alfred S. Conston MD, Vincent A. Galdi MD, Lou Jouberti,- Cancer Volume 54, Issue...more
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