Treatments rosacea - azelaic acid
Treatments rosacea - azelaic acid
Rosacea can be treated effectively with various topical medicines like Azelaic acid cream. It is caused due to the elevated levels of the peptide cathelicidin and elevated levels of stratum corneum tryptic enzymes (SCTEs). There are various causes that can lead to this chronic skin disease. It usually produces redness flushing of the skin, pustules and papules.
Azelaic acid is effective against a number of skin conditions, and for mild to moderate acne, i.e. both comedonal acne and inflammatory acne. It is applied topically in a cream formulation of 20%. Its antibacterial property reduces the growth of bacteria in the follicle. Its Keratolytic and comedolytic properties return to normal the disordered growth of the skin cells, lining the follicle. It scavenges free radicals and reduces inflammation and pigmentation. Due to its non toxic nature it is usually well tolerated by most patients.
It is used to treat rosacea due to its ability to reduce inflammation. If left untreated rosacea may worsen. It is marked by redness (erythema) of the face, flushing of the skin, presence of hard pimples (papules) or pus-filled pimples (pustules), and small visible spider-like veins called telangiectasias. In later stages of the disease, the face may swell and the nose may take on a bulb-like appearance called rhinophyma. There are four subtypes of rosacea, they are erythematotelangiectatic rosacea, papulopustular rosacea, phymatous rosacea, and ocular rosacea. Patients suffering from it may have more than one subtype present. Heredity and environmental factors are believed to be the main cause of this disease. It mostly affects the face, nose, cheeks, forehead, and chin. But some people experience symptoms on their neck, back, scalp, arms, and legs as well. People with rosacea do not have blackheads. An early stage of rosacea includes repeated episodes of flushing. Later stage appears to be persistently red. telangiectasia appear on the nose and cheeks, along with inflamed papules and pustules. Eventually, the skin may take on a rough, orange peel texture. Sometimes it may affect eyes called ocular rosacea. Telangiectasia may appear around the borders of the eyelid, the eyelids may be chronically inflamed, and small lumps called chalazions may develop. The cornea of the eye, the transparent covering over the lens, can also be affected, and in some cases vision will be affected.
There is no known specific cause of rosacea. It can affect at any age with any skin type. According to many experts the multiple factors may lead to an overreaction of the facial blood vessels, which triggers flushing. Over time, persistent episodes of redness and flushing leave the face continually inflamed. There is no specific test for the disease. Blackheads and cysts, however, are seen in acne patients, but not in those with rosacea. Other diseases that produce some of the same symptoms as rosacea include perioral dermatitis and systemic lupus erythematosus. Some believe it is due to certain genetic factors, while some researchers suspect a bacterium or other infectious agent to be the cause. One of the newest suspects is a bacterium called Helicobacter pylori, which has been implicated in causing many cases of stomach ulcers but the evidence here is mixed. Other investigators have observed that a particular parasite, the mite Demodex folliculorum, can be found in areas of the skin affected by rosacea. The mite can also be detected, however, in the skin of people who do not have the disease. It is likely that the mite does not cause rosacea, but merely aggravates it. The mainstay of treatment for rosacea is oral antibiotics. Patients frequently take a relatively high dose of antibiotics until their symptoms are controlled, and then they slowly reduce their daily dose to a level that just keeps their symptoms in check. A topical agent applied directly to the face may be tried in addition to an oral antibiotic.
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