Langerhans Cell Histiocytosis Treatment In India For International Patients
Langerhans cell Histiocytosis treatment in India is possible in India
. Many of the most advanced medical facilities in the world exist outside of the United States, with specific programs carefully designed to attract international travelers such as Nigerian citizens. In fact, these hospitals have spent the last decade preparing for the explosive growth of medical tourism, specifically adhering to the same high standards that we in the United States have come to trust. Why do people want to travel half way around the world to undergo medical procedures? The answer is simple, Affordable healthcare, not to mention a little bit of leisure and peaceful recuperation in complete anonymity. India has now become a great destination for treatment abroad because of the significantly lower currency exchange rate and this equates to Incredible Savings. Langerhans cell Histiocytosis treatment can be done in India at affordable cost.
What is Langerhans cell Histiocytosis?
Langerhans cell Histiocytosis is a proliferation of dendritic mononuclear cells with infiltration into organs locally or diffusely. Most cases occur in children. Manifestations may include lung infiltrates; bone lesions; rashes; and hepatic, hematopoietic, and endocrine dysfunction. In Langerhans cell Histiocytosis, abnormally proliferating dendritic cells infiltrate one or more organs. Bones, skin, teeth, gingival tissue, ears, endocrine organs, lungs, liver, spleen, lymph nodes, and bone marrow may be involved. Organs may be affected by infiltration, causing dysfunction, or by compression from adjacent enlarged structures. In about half of patients, more than one organ is involved.
Symptoms and Signs of Langerhans Cell Histiocytosis
Symptoms and signs vary considerably depending on which organs are infiltrated in Langerhans cell Histiocytosis. The syndromes are described by their historical designations, but few patients present with classic manifestations.
Eosinophilic granuloma: Solitary or multifocal eosinophilic granuloma (60 to 80% of LCH cases) occurs predominantly in older children and young adults, usually by age 30; incidence peaks between ages 5 and 10 yr. Lesions most frequently involve bones, often with pain, the inability to bear weight, or both and with overlying tender (sometimes warm) swelling.
Hand-Schuller-Christian disease: This syndrome (15 to 40% of LCH cases) occurs in children aged 2 to 5 yr and in some older children and adults. This systemic disorder classically involves the flat bones of the skull, ribs, pelvis, scapula, or a combination. Long bones and lumbosacral vertebrae are less frequently involved; the wrists, hands, knees, feet, and cervical vertebrae are rarely involved. In classic cases, patients have exophthalmos caused by orbital tumor mass. Rarely, vision loss or strabismus is caused by optic nerve or orbital muscle involvement. Tooth loss caused by apical and gingival infiltration is common in older patients.
Prognosis
Prognosis is good for patients with both of the following:
Disease restricted to skin, lymph nodes, or bones
Age > 2 yr
With treatment, almost all such patients survive.
Morbidity and mortality are increased in patients with multiorgan involvement, particularly those with
Age < 2 yr
Involvement of the hematopoietic system, liver, lungs, or spleen
With treatment, the overall survival rate for patients with multiorgan disease is about 80%. Death is more likely among at-risk patients who do not respond to initial therapy. Disease recurrence is common. A chronic remitting and exacerbating course may occur, particularly among adults.
Treatment of Langerhans cell Histiocytosis
The treatment of Langerhans cell Histiocytosis include following:
Supportive care
Sometimes hormone replacement therapy for hypopituitarism
Chemotherapy for multiorgan involvement
Sometimes surgery or radiation therapy (usually for single bone involvement)
Because these syndromes are rare and complex, patients are usually referred to institutions experienced in the treatment of Langerhans cell Histiocytosis. General supportive care is essential and may include scrupulous hygiene to limit ear, cutaneous, and dental lesions. Debridement or resection of severely affected gingival tissue limits oral involvement. Seborrhea-like dermatitis of the scalp may diminish with use of a selenium
-based shampoo twice/wk. If shampooing is ineffective, topical corticosteroids are used in small amounts and briefly in small areas.
Chemotherapy is indicated for patients with multiorgan involvement. Protocols sponsored by the Histiocyte Society are used; treatment protocols vary according to the risk category. Almost all patients with a good response to therapy can stop treatment. Protocols for poor responders are under study.
Local surgery or radiation therapy is used for disease involving a single bone and, rarely, when multiple lesions or multiple bones are involved. Easily accessible lesions in noncritical locations undergo surgical curettage. Radiation therapy involving megavoltage equipment may be given to patients at risk of skeletal deformity, visual loss secondary to exophthalmos, pathologic fractures, vertebral collapse, and spinal cord injury or to patients with severe pain. Doses of radiation are considerably less than those used to treat cancer. Surgery and radiation therapy should be done by specialists experienced in treating Langerhans cell Histiocytosis.
Patients with multiorgan disease that progresses despite standard therapy usually respond to more aggressive chemotherapy. Patients who do not respond to salvage chemotherapy may undergo bone marrow transplantation, experimental chemotherapy, or immunosuppressive or other immunomodulatory therapy.
Recovery from Langerhans cell Histiocytosis
The vast majority of patients will survive the disease. Some may develop life-long chronic problems, while other remains symptom free. In some cases, the disease is fatal. Usually these are very young infants. They have a rapid downhill course, and do not respond to any known treatments. The physician will be able to discuss the patient's likelihood of responding and doing well. Whether or not the disease responds to treatment will often depend on the extent of organ involvement. However, it is often difficult to make definite predictions, much to the frustration of the physician and family.
Why to choose Forerunners Healthcare India?
Langerhans cell Histiocytosis treatment in India is done under specialized team. Forerunners will guide you, step-by-step, through the entire process. Within a short period of time, you will receive valuable assistance from us on how to help facilitate the planning of your medical holiday. Forerunners provide the highest possible standard of treatment in a caring, compassionate and personalized environment. We are the largest group of dedicated specialists in cancer treatment, supported by a team of experienced scientists, nurses and counselors, in a network of local cancer centers. Our reputation attracts patients from overseas countries for their various treatments. We have the most extensive and convenient network of local cancer centers; the most comprehensive range of treatments and the most advanced laboratory technology for treatment.
For more details on Langerhans cell Histiocytosis treatment, visit us at www.forerunnershealthcare.com or mail your queries at enquiry@forerunnershealthcare.com or call us at: +91-9371136499, +91- 9860755000 (International) / + 1-415-599-2537 (USA) / +44-20-8133-2571 (UK)
by: ssswati
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