Four Kinds Of Plant Extracts Inhibit Growth Of Liver Cancer Cell
Liver cancer is one of the common malignant tumors in China
. Its mortality ranks third among malignant tumors of digestive system. It is just after stomach cancer and esophageal cancer and seriously affects people's health and life. To find the anti tumor active ingredient from plants is an important area of cancer research. Xinjiang is the kingdom of Chinese wild plant extracts. The special light, heat resources and a strong temperature difference between day and night breed biomes which have special anti-mutagenic pharmacological effects. Study focus on Xinjiang plant multiflora rose, black currant, oleaster, and almond extract. They inhibit human hepatoma cells growth. It is designed to accumulate data for the further development of anticancer drugs.
The application of low doses of multiflora rose, black currant, tumor cell growth and proliferation by the inhibition of cell density is lower than the negative control group, cells scattered in the volume is reduced, the lack of three-dimensional sense of individual broken cell aggregation. In dose results in the range between high and low doses. Different concentrations of test substances on human hepatocellular carcinoma tumor cells QCY-7704 inhibition of multiflora rose, black currant, Elaeagnus angustifolia and almond extract inhibition with increasing dose and strengthened; the inhibitory effect of the multiflora rose and black currant With the extension of the duration of action and strengthened; the antitumor effect of Elaeagnus angustifolia and almond and time dependencies.
The tumor is the first killer of human health, the development of anti-tumor components from plants is one of the hotspots of anti-cancer research. Xinjiang, a vast territory and rich plant resources, multiflora rose, black currant, L., almond widely distributed in Xinjiang. Different concentrations of brier, black currant, L., almond extract objects outside the human hepatoma cell role, using the MTT assay measuring OD values and observe the changes in cell morphology, initial screening of anti-cancer drugs.
High doses of pharmaceutical raw materials multiflora rose, black currant, elaeagnus angustifolia and almond extract significantly inhibited the proliferation of human hepatoma cell line QCY-7404. These results enhance immunity, anti-mutagenic, anti-tumor effect is consistent with the multiflora rose, black currant, L., almond. Especially multiflora rose and black currant group of human hepatocellular carcinoma tumor cells appear broken and wrinkled, fuzzy boundaries, the light is poor; the lack of three-dimensional sense; a small number of cells, spacing, most of the cell volume, condensation phenomena such as smaller doses more large role in the longer, the more obvious morphological changes, this results in the MTT assay has been further demonstrated. Attached is an important condition for the growth and proliferation of adherent cells, usually one cell surface glycoprotein secreted by the cell, its cell motility, especially attached to the support material plays an important role on the growth and change the nature of the cell coat inhibit paste attached cells to flake off from the support material.
The MTT assay is widely used for testing tumor susceptibility determination. Mitochondria dehydrogenase in normal activity living cell can reduce MTT to purple. And there is a linear relationship between the OD value of the generated and the number of cell survival. The test substance group of tumor cell is limited. OD values are significantly lower than the negative control group. Multiflora rose, black currant, elaeagnus angustifolia, and almond extract may interfere with cell metabolism and change nature of the cell coat to inhibit tumor cell proliferation. Action mechanism and active ingredients of multiflora rose, black currant, elaeagnus angustifolia and almond extract in inhibiting human hepatoma cell line need to be further studied.
Source:http://www.cospcn.com
by: anelwew
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