Another interesting study is called, The role of extrapleural pneumonectomy in malignant pleural mesothelioma. A Lung Cancer Study Group trial by VW Rusch, S Piantadosi and EC Holmes - Memorial Sloan-Kettering Cancer Center, New York, N.Y. The Journal of Thoracic and Cardiovascular Surgery, Vol 102, 1-9 Here is an excerpt: Malignant pleural mesothelioma is usually a fatal cancer for which operation has been the mainstay of treatment because...more
Another interesting study is called, Localized mesothelioma of the pleura: benign and malignant variants by N Okike, PE Bernatz and LB Woolner - The Journal of Thoracic and Cardiovascular Surgery, Vol 75, 363-372. Here is an excerpt: Mesothelioma, even of the pleura alone, is a ubiquitous pathological designation. The diffuse variety is associated with an ominous prognosis. The localized mesothelioma generally has been assumed to be benign. A...more
Another interesting study is called, Modified RECIST criteria for assessment of response in malignant pleural Mesothelioma by M. J. Byrne and A. K. Nowak - Ann Oncol (2004) 15 (2): 257-260. Here is an excerpt: Abstract - Background: The growth pattern of malignant pleural mesothelioma makes the use of RECIST (response evaluation criteria in solid tumours) response criteria difficult. We have developed and validated Modified RECIST criteria adapted to the growth pattern of malignant pleural mesothelioma. Patients and methods: We evaluated 73 patients from two clinical trials of cisplatin/gemcitabine chemotherapy in malignant pleural mesothelioma. Tumour thickness perpendicular to the chest wall or mediastinum was measured in two positions at three separate levels on thoracic CT scans. The sum of the six measurements defined a pleural unidimensional measure. Bidimensionally measureable lesions were measured unidimensionally as for RECIST. All measurements were added to obtain the total tumour measurement. A reduction of at least 30% on two occasions 4 weeks apart defined a partial response; an increase of 20% over the nadir measurement, progressive disease. The validity of the...more
Another interesting study is called, Mesothelioma: profile of keratin proteins and carcinoembryonic antigen: an immunoperoxidase study of 20 cases and comparison with pulmonary adenocarcinomas. - Am J Pathol. 1982 July; 108(1): 8087 by J. M. Corson and G. S. Pinkus. Here is an excerpt: Abstract - The distribution of keratin proteins and...more
Another interesting study is called, Value of the Mesothelium-Associated Antibodies Thrombomodulin, Cytokeratin 5/6, Calretinin, and CD44H in Distinguishing Epithelioid Pleural Mesothelioma from Adenocarcinoma Metastatic to the Pleura by P M Cury M.D., D N Butcher, C Fisher M.D., B Corrin M.D. and A G Nicholson D.M. - Mod Pathol 2000;13(2):107112. ...more
Another interesting study is called, Codeletion of p15 and p16 in primary malignant mesothelioma. By Xio S, Li D, Vijg J, Sugarbaker DJ, Corson JM, Fletcher JA. - Oncogene. 1995 Aug 3;11(3):511-5. Department of Pathology, Children's Hospital, Boston, Massachusetts. Here is an excerpt: Abstract - The p15 and p16 CDK4 inhibitor genes map within the chromosome band 9p21 region deleted frequently in malignant mesothelioma and other cancers. p16 has been implicated recently as a potential target of 9p21 deletions in mesothelioma, but the role of this gene is uncertain because deletions have been detected more often in established cell lines than in primary tumor specimens. We determined p15 and p16 copy number by fluorescence in situ hybridization with a P1 contig in 50 primary mesotheliomas. Codeletion of p15 and p16 was found in 72% of mesotheliomas, including all cases with spindle-cell components (n = 21) and total deletion of p15 and p16 was found in several mesotheliomas that lacked cytogenetic deletion of the chromosome 9 short arm. Point mutations were not found, however, in exon 2 of retained p15 and p16 alleles from seven mesotheliomas. These findings demonstrate that p15,...more
Another interesting study is called, Value of calretinin immunostaining in differentiating epithelial mesothelioma from lung adenocarcinoma. By Ordez NG. The University of Texas M.D. Anderson Cancer Center, Houston 77030 - Mod Pathol. 1998...more
Another interesting study is called, Neoadjuvant Chemotherapy Followed by Extrapleural Pneumonectomy in Malignant Pleural Mesothelioma by Walter Weder, Peter Kestenholz, Christian Taverna, Stefan Bodis, Didier Lardinois, Monika Jerman, Rolf A. Stahel...more
An abdominal hernia occurs when either fatty tissue or an organ in the abdomen protrudes through a weak point or tear in the muscles or tissues around it. The protrusion can be labeled either as reducible, which means it can be pushed...more
American Cancer Treatment Organization is created in order to help people stay well or treat a persons problem. In majority of all cases people find themselves left alone and neglected by other individuals and the society as well. This is the main...more
Mobile phone deals are gaining popularity amongst the mobile lovers. These mobile phone deals have made it easier for the customer to get latest multifunctional handsets at pocket friendly rates. Previously it was a big problem for the...more
The effects of a migraine can be so severe, that some persons will do just about anything to get some relief. This relief can be in the form of medication or alternative treatments.Migraines have been attributed in part, to changes in the body...more