Treatment Of Docetaxels Drug Leakage
Docetaxel is also known as yew, patel and taxotere
, docetaxel. It can promote tubulin to form microtubules and inhibit depolymerization of the latter. Thus it enhances the dimer assembly of microtubules, prevents its poly and eventually leads to the spindle abnormalities to inhibit mitosis. It has a good effect on ovarian cancer, breast cancer and non-small cell lung cancer. At the same time, it has a certain effect on the head neck cancer, small cell lung cancer, stomach cancer, melanoma and soft tissue sarcoma.
Chemotherapy drugs outside the leakage has been the Oncology most afraid of, what, the most likely to cause patient suffering and cause of nursing disputes. Docetaxel solution ph value of about 6.5, a weak acid. Leakage caused by chemical stimulation, causing inflammation of the organization to the organization. medication instructions and pharmacopoeia no adverse reactions and handling of drug leakage outside race. Only the emphasis on the processing of PVC material infusion to prevent allergic reactions. According to the classification of chemicals extravascular leakage, will be divided into stimulant medications. The so-called irritant drugs outside leakage can cause burns or mild inflammation without necrosis.
After outside leakage of docetaxel, the local skin feels blisters, itching and pain. If it is not handled properly, secondary infection can cause serious adverse consequences. During docetaxel treatment, the doctors and nurses should be first in patients with vascular assessment of the master puncture technique, and to inform patients of precautions to reduce the puncture by the movements, but should also step up inspections, ask the patient infusion local with or without pain or tingling in the application of normal saline infusion is completed, rinse the blood vessels, and the timely detection of problems and timely processing.
Nurses should distinguish the difference between extravasation and leakage of the past, leakage, infiltration collectively referred to extravasation. In fact, extravasation is due to the hardening of the arteries in patients with increased fragility, age and long input strong irritant drugs and other factors, causing the permeability of blood vessels increases, the slow penetration of liquid by a blood vessel to the organization. While the leakage due to puncture of the technical problems or activities and the needle puncture site in patients with fixed wrong, cause the needle the prolapse extravascular or perforation of blood vessels caused by liquid leakage into the organization.
There are methods and treatments for blistering pharmaceutical raw materials (refers to the outside leakage causing local tissue necrosis) and its local external leakage. But it dose not specify the frequency and time of partial closure. According to clinical experience in handling, after leakage of blistering drug, the partial closure is necessary. It should be taken once a day. After three days in a row, it does not appear the leakage of local necrosis. If the partial closure of stimulant medication has not been taken for three days, whether the patients blisters are related to closure need further study.Source:http://www.cospcn.com
by: anelwew
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