Natural Anticancer Clinical Drug Shows An Increasing Trend
Plant alkaloids and other natural medicines are leading categories in antineoplastic agents
. They show an increasing trend in the use of clinical drugs. It leads to the continuous growth of Chia seed market capacity. In 2000, the global anti-cancer drugs market value was $ 23.613 billion with an increase of 3.9 percent over the previous year. The 20 kinds of anti-cancer drugs in the best-selling 400 kinds of prescription drugs have a sale of $ 9.4 billion, which accounts for 37% of the natural plant alkaloid extracted drugs. In this class of drugs, natural and semi-synthetic paclitaxels sales are nearly $ 2.5 billion.Camptothecin derivative drugs have already been over one billion U.S. dollars.
At present, in the Chinese anticancer drugs market, natural plant alkaloid extract drug category with better sales are paclitaxel, hydroxycamptothecin vinorelbin, lentinan docetaxel and elemi ene. These drugs play a major role not only in the micro-protein synthesis in cancer cells by interference, but also has an active role in induction of apoptosis, antiangiogenic, and an irreplaceable position in the established anticancer drugs. The rise of the clinical needs of these drugs, to promote the upstream bulk drugs market has become increasingly popular.
Hydroxycamptothecin from davidia involucrata can be extracted from the plant Camptotheca acuminata to trace alkaloid, has significant anti-cancer activity is the most characteristic plant alkaloid. The drug selectively inhibits topoisomerase intervention in DNA replication, is a commonly used anticancer drug. The main products of the camptothecin derivative are irinotecan.
Taxol is a natural plant-based anti-tumor drugs, extraction, separation from the bark of the yew Pacific brevifolia taxadiene ring terpenoids. Mainly used for the treatment of ovarian cancer, breast cancer and non-small cell lung cancer and Kaposi network malignancies. Taxol is cell inhibitor class of anticancer drugs can interfere with tubulin synthesis of cancer cells to anticancer effect, had no effects on normal cells. Its most solid tumors have a strong inhibitory effect, especially in patients with advanced ovarian cancer, breast cancer, non-small cell lung cancer and Kaposi's sarcoma efficacy, fewer side effects. At the same time, it is also used for the treatment of rheumatoid arthritis, skin disorders. The product injection, supplemented by powder injection, capsules, gels.
Although taxol is bristol-myers squibb's exclusive products, reached the peak of sales in 2000 of $ 1.592 billion, the bulk drugs market is about 200 million U.S. dollars. With the production of many companies to join, paclitaxel prescription drugs have declined, and ultimately will benefit the majority of cancer patients.
Docetaxel also belongs to microtubule depolymerization inhibitor. It is a non-active compounds extracted from the needles of the European berry yew. The products are mainly the injections, supplementing by powder injection and capsules. They are chemotherapy drugs using for breast cancer and non-small cell lung cancer. Docetaxel products yield is 2%.Its effect is better than paclitaxel. With the same dose, its anti-microtubule depolymerization capacity is twice than that of paclitaxel by inhibiting cell division. It has a more widely application in anti-tumor spectrum and has more practical value in economy.
by: anelwew
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2024-2-20 01:44
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