Another interesting study is called, Expression is common in malignant Mesothelioma by G. KAFIRI, D.M. THOMAS, N.A. SHEPHERD, T. KRAUSZ, D.P. LANE, P.A. HALL Histopathology - Volume 21, Issue 4, pages 331334, October 1992. Here is an excerpt: The p53 tumour suppressor gene has been shown to be frequently mutated in a wide range of human neoplasms. This is accompanied by increased levels of p53 protein which become immunologically detectable in...more
Another interesting study is called, Genetic alteration of the -catenin gene (CTNNB1) in human lung cancer and malignant mesothelioma and identification of a new 3 p 21.3 homozygous deletion Oncogene 2001, vol. 20, no31, pp. 4249-4257 by Shigemitsu Kikuo; Sekido Yoshitaka ; Usami Noriyasu; Mori Shoichi; Sato Mitsuo; Horio Yoshitsugu; Hasegawa Yoshinori; Bader Scott A.; Gazdar Adi F. ; Minna John D.; Hida Toyoaki; Yoshioka Hiromu; Imaizumi...more
An interesting study is called, Dickkopf-1 antagonizes Wnt signaling independent of -catenin in human Mesothelioma - Biochemical and Biophysical Research Communications - Volume 323, Issue 4, 29 October 2004, Pages 1246-1250 by Amie Y. Lee, Biao He, Liang You, Zhidong Xu, Julien Mazieres, Noemi Reguart, Iwao Mikami, Sonny Batra and David M. Jablons Here is an excerpt: Abstract - Dickkopf-1 (Dkk-1) is a secreted protein that acts as a potent inhibitor of the Wnt signal transduction pathway. It is thought that the antagonistic effect of Dkk-1 is specific to the canonical (Wnt/-catenin) pathway. In this study, we demonstrate that restoration of Dkk-1 expression suppresses cell growth and induces apoptotic cell death in -catenin-deficient mesothelioma cell lines H28 and MS-1. Furthermore, we found that a small-molecule inhibitor of JNK inhibited the apoptosis induced by Dkk-1 overexpression in these cells. Together, our data suggest that Dkk-1 may be able to antagonize Wnt signaling and exert its tumor suppressive effects through -catenin-independent non-canonical pathways.Another interesting study is called, Lysis of human malignant mesothelioma cells by natural killer (NK) and...more
Another interesting study is called, Lymph Node Metastasis: as the Initial Manifestation of: Malignant Mesothelioma: Report of Six Cases by Sussman, Jeffrey M.D.; Rosai, Juan M.D. Here is an excerpt: Abstract - We present six cases in which lymphadenopathy was the initial manifestation of malignant mesothelioma. In five cases, the primary tumor...more
An interesting study is called, Early Response Evaluation in Malignant Pleural Mesothelioma by Positron Emission Tomography With [18F] Fluorodeoxyglucose by Giovanni L. Ceresoli, Arturo Chiti, Paolo A. Zucali, Marcello Rodari, Romano F. Lutman, Silvia Salamina, Matteo Incarbone, Marco Alloisio, Armando Santoro - Journal of Clinical Oncology, Vol...more
Another interesting study is called, The Human Type 2 Iodothyronine Deiodinase Is a Selenoprotein Highly Expressed in a Mesothelioma Cell Line by Cyntia Curcio, Munira M. A. Baqui, Domenico Salvatore, Bertrand H. Rihn, Steve Mohr, John W. Harney, P. Reed Larsen and Antonio C. Bianco - August 10, 2001 The Journal of Biological Chemistry, 276, 30183-30187 Here is an excerpt: Abstract - Types 1 and 3 iodothyronine deiodinases are known to be selenocysteine-containing enzymes. Although a putative human type 2 iodothyronine deiodinase (D2) gene (hDio2) encoding a similar selenoprotein has been identified, basal D2 activity is not selenium (Se)-dependent nor has D2 been labeled with75Se. A human mesothelioma cell line (MSTO-211H) has recently been shown to have 40-fold higher levels ofhDio2 mRNA than mesothelial cells. Mesothelioma cell lysates activate thyroxine (T4) to 3,5,3-triiodothyronine with typical characteristics of D2 such as low K m (T4), 1.3 nm, resistance to propylthiouracil, and a short half-life (30 min). D2 activity is 30-fold higher in Se-supplemented than in Se-depleted medium. An antiserum prepared against a peptide deduced from theDio2 mRNA sequence precipitates a...more
Another interesting study is called, Value of thrombomodulin immunostaining in the diagnosis of Mesothelioma by N.G. ORDEZ Histopathology Volume 31, Issue 1, pages 2530, July 1997. Here is an excerpt: Aims: Even with the benefit of...more
Have you tried looking in the mirror only to see your shining face? Oily skin is a common problem worldwide. It is because of too much oil production by the sebaceous glands. The oil produced by these glands are necessary to keep your skin healthy....more
Promotional products are oftentimes put to use as marketing tools by most products. But did you know that they can also be used as announcing instruments for charitable functions? Yes! These objects can be maximized as bequests for information drives...more
Your doctor is able to prescribe many treatments for the common complaint of piles, and there are also many that you are able to buy over-the-counter at your local pharmacy, but all these medications have one thing in common. They all treat the...more
Advancements in medical science have led to the development of a range of surgeries to cure vision defects. Laser vision correction methods are the most popular among the contemporary eye surgeries. These methods utilize a special kind of laser...more
Does Dynamiclear really work? Or it is just a Dynamiclear scam? Can it really clear all your Herpes away? Worrying about your Herpes is just as hard as thinking about how to treat it. There are many products in the market nowadays that are claiming...more