Office is a place in which business oriented professional activities are carried out. The office space can be utilized in varying methods, depending upon the organizational structure and departmentation of staff and working processes. Office space management is a function specific task and there is no one best way of utilizing your available space, because all the workings of the organization depend upon the unique chain of command and hierarchy...more
Author: Jessica CastroDefinitionAmyloid precursor protein (APP) is a single transmembrane protein that undergoes sequential proteolysis to generate multiple peptides, including the amyloid beta peptide the major component of the senile plaques that are diagnostic hallmarks of Alzheimer disease (AD).DiscoveryIn 1984, Glenner and Wong purified APP derived from the twisted beta-pleated sheet fibrils present in cerebrovascular amyloidoses and in the...more
Author: Jessica CastroAmylin or Islet amyloid polypeptide (IAPP), a 37-amino acid peptide is secreted by beta-islet cells of the pancreas and a major component of the amyloid deposits in persons with type 2 diabetes mellitus. Amylin may be referred to as insulin’s “fraternal twin” as it is constitutively expressed with insulin in response to elevations of plasma glucose.DiscoveryThe knowledge of occurrence of amyloid deposits in islets of Langerhans, major pathologic feature of diabetics has been known for a century. But, the discovery of amylin as a major component of amyloid deposits was by two independent groups in 19871, 2.Structural characteristicsThe human amylin has an amino acid sequence KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY, with a disulfide bridge between cysteine residues 2 and 7. The features, amidated C-terminus and the disulfide bridge are necessary for the full biological activity of amylin3. Amylin amino acid sequence is 46% and 43% identical to those of the calcitonin gene-related neuropeptides CGRP-2 and CGRP-1. The (20-29) fragment of amylin is critical to the pathogenesis of islet amyloid4.Mechanism of actionAmylin is synthesized, packaged within the golgi...more
What is it anyway? It is a great alternative and a way to train your dog without the use of incentives like food or toys. Plus, this will serve as a good exercise and a worthwhile activity you and your dog can do on your free time. There are many types of equipment you can choose from. This may depend on several things. First thing you have to know...more
Author: Anne DavidsHave you been having trouble with your life for the past few weeks now because you feel that you don't function normally anymore in your daily activities since the day the love of your life left you? Don't worry because you can still bring back the love of your life and make your relationship even work this time with the help of...more
Author: taamivThe APA format is the short form of American Psychological Association writing style, and this has been formulated to cite sources in psychology and certain types of science documentation. The documentation style is very rigorous and is a being implemented with severs other disciplines like medicine and education.The specification of the APA format is very difficult to document but a few important ones can be discussed here. The American psychological format requires in text citations in the form of parenthesis to credit the author. The parenthesis should include the author’s name as well as the publication date. And if no information is available ‘n.d’ must be written there. Footnotes form an important feature of academic papers written according to the APA format. Today, footnotes are being applied commonly. This is in high contrast to earlier times, when footnotes were the only citation source. Today authors are required to have knowledge about footnotes in case they are asked to include it in their academic papers. Endnotes are very similar to footnotes. In fact they are can be considered as a n extension to footnotes. These; provide information about the...more
Author: Aarkstore Enterprise SummaryThis report is an essential source for in-depth information and data relating to India Ophthalmic/Ophthalmology Devices market. It also offers detailed and comprehensive coverage of market revenue, volume,...more
An increasing number of men are saying yes to undergo cosmetic surgery whether it be invasive or non-surgical nowadays due to more procedures, less downtime, and wanting to take care of their appearance for aesthetic reasons similar to what women...more
Author: JeffThe method of identifying, quantifying and prioritizing the vulnerabilities in a system according to type is known as vulnerability assessment. Vulnerability assessments are performed for a variety of systems including nuclear power...more
Author: James Goodridge In a world where no one has the time to relax and every one is working hard, stress is bound to happen. And if you are a victim of stress at school, college, university, or workplace, you need to read on. We all are so busy...more
Author: Anne DavidsHave you been so scared and so worried for the past few months because you feel that you really can't seem to live without your wife? Do you feel that you are not a complete person anymore since the day your wife left you? I truly...more
Learning another language is something anyone can do. German is a popular language that people want to learn. It is said that the best time to learn a second language, such as German, is in the first 5 years of life. Our minds are sponges then. But...more