subject: Medications Used in the Treatment of Gout [print this page] Medications Used in the Treatment of Gout
Completely different medicines are prescribed to treat different symptoms of gout and joint ache:
Treat acute gout attacks and stop future attacks
Scale back the chance of gout problems, such because the deposits of urate crystals that trigger nodules to form underneath the pores and skin (tophi)
Medication used to deal with acute assaults and stop future assaults include:
Nonsteroidal anti-inflammatory medicine (NSAIDs). NSAIDs could management irritation and pain in people with gout. Your doctor may prescribe a better dose to stop an acute assault, followed by a decrease each day dose to forestall future attacks.
NSAIDs include over-the-counter options comparable to ibuprofen (Advil, Motrin, others) and naproxen (Aleve, others), as well as extra highly effective prescription NSAIDs resembling indomethacin (Indocin). NSAIDs carry dangers of stomach pain, bleeding and ulcers.
Colchicine. In case you're unable to take NSAIDs, your doctor may advocate colchicine, a sort of pain reliever that effectively reduces gout pain - particularly when started quickly after signs appear. The drug's effectiveness is offset typically, however, by intolerable side effects, similar to nausea, vomiting and diarrhea.
After an acute gout assault resolves, your doctor might prescribe a low daily dose of colchicine to stop future attacks.
Corticosteroids. Corticosteroid drugs, such because the drug prednisone, might management gout irritation and pain. Corticosteroids could also be administered in tablet form, or they can be injected into your joint. Corticosteroids are typically reserved for individuals who cannot take either NSAIDs or colchicine.
Unwanted effects of corticosteroids could embody thinning bones, poor wound healing and a decreased means to combat infection. To reduce the chance of these critical negative effects, your physician will attempt to find the lowest dose that controls your symptoms and prescribe steroids for the shortest possible time.
Drugs used to prevent the problems related to frequent gout assaults embrace:
Medication that blocks uric acid production. Drugs called xanthine oxidase inhibitors, together with allopurinol (Zyloprim, Aloprim) and febuxostat (Uloric), restrict the quantity of uric acid your physique makes. This will likely decrease your blood's uric acid stage and cut back your danger of gout. Uncomfortable side effects of allopurinol include a rash and low blood counts. Febuxostat unwanted effects embody rash, nausea and diminished liver function.
Xanthine oxidase inhibitors may set off a new, acute assault if taken before a current assault has totally resolved. Taking a brief course of low-dose colchicine earlier than beginning a xanthine oxidase inhibitor has been discovered to significantly cut back this risk.
Remedy that improves uric acid removal. Probenecid (Probalan) improves your kidneys' ability to take away uric acid from your body. This will likely decrease your uric acid ranges and cut back your risk of gout, however the degree of uric acid in your urine is increased. Side effects include a rash, abdomen ache and kidney stones.
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