subject: Acetyl Cysteine – A powerful treatment for Paracetamol Over Dose ! [print this page] The reason for this is due to the mechanism by which paracetamol is processed by the liver. The paracetamol molecule is broken down into four main metabolites in the liver. Three of these are completely harmless and they account for up to 80% of the by products of metabolism. The remaining 20% is converted to a highly reactive compound known as n-acetyl-p-benzoquinone imine, otherwise known as NAPQI for short. Fortunately for your liver, this toxic compound can be rendered harmless using the bodies most abundant cellular antioxidant, glutathione.
This is why small doses of paracetamol are safe, since the liver is able to process the small quantities of NAPQI safely using it's stores of glutathione. However, if too much is taken then large amounts of NAPQI are produced and the livers' stores of glutathione are rapidly used up. Once they are gone, then the free NAPQI causes havoc by damaging proteins and nucleic acids in liver cells, killing them off.
Acetyl Cysteine A powerful treatment for Paracetamol Over Dose !
By: Church Hom
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