subject: What is the eculizumab mechanism of action? [print this page]
The eculizumab mechanism of action is binding to C5 protein in the blood. This blockage prevents the splitting of the C5 enzyme into C5a and C5b. Moreover, this helps to protect the healthy cells because C5a blockage helps to stop blood vessels from becoming overly leaky. Also, C5b blockage aids in the creation of the C5b-9 complex, which punches holes in cell walls to destroy them.
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