subject: Scientists Found That Differences Between Left And Right Human Gene Family - Gene - Pharmaceutical [print this page] Scientists have discovered a first stage in development to play a key role in the gene family, at this stage, the embryos are identifiable as the left and right side of the body and begin to determine organ placed in the body position. The body was found in mice can a better understanding of certain birth defects of humanity is how it happened. The study was published in the Jan. 24 issue of "Nature Cell Biology " magazine online edition.
Built around the study of embryonic development of symmetry breaking mechanism on top. Osaka University geneticist Dr. Tian Hong Bin and his colleagues showed that, in the embryonic node in the region of the cell surface of cilia formation in the embryo outside the left to flow, in turn, to know which side is left of the embryo. The reason is that ciliated cells back towards the node, and the tilt to the embryonic tail.
This unique position, with the combination of cilia formation of a clockwise movement to the movement of the left, along the left and right embryonic symmetry is broken. According to research, to establish if there is no directional flows, the organism is in the body the wrong side of the development of the organs, thereby reducing their chances of survival.
Know the location of the node cilia on the embryonic development of the important relationship between stages, the researchers decided to further observation of a group called "scattered" and it can lead cilia gene family moved to the back of the node cells. In the "idle" gene family for many years study, the researchers were closed by 3 "Scattered" gene in a mouse model to develop, in order to study their function. Ultimately, the researchers found that "scattered" gene can activate PCP pathway, this pathway will help determine the location of cells and tissue information.
First author paper, the macro Hamada Hashimoto is a graduate student lab, and through a microscope connected with high-speed cameras, on the survival of mouse embryos in the ciliary movement was monitored and observed to do with the position of cilia development process of change. About symmetry breaking occurs in the earliest developmental stages before, ciliated cells in the central node, with the progress of development, ciliated cells gradually shifted to the back.
Researchers cilia in normal mouse embryos and with the "scattered" genetic mutant embryos the cilia were compared. They found that embryos with a mutation in the ciliated cells in the nodes of non-normal position, thus unable to form the left to flow.
Researchers said, a finding that provides the most basic level of human development of the information, that is, How was about human difference, and ultimately how these differences led to the growth of the left heart, and liver growth on the right. On a clear understanding of the process of embryonic development will contribute to a better understanding of the causes of human birth defects, and find ways to correct these deficiencies.
by: gaga
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