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Iron deficiency in mothers a cause of brain disability in children

Iron deficiency in mothers a cause of brain disability in children
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Iron deficiency in mothers a cause of brain disability in children


Iron deficiency a cause of brain disability in childrenPROF G.M.WANI MVSVOG,PHDVOG ,DVM (GERMANY)Iron deficiency and resultant anaemia in women is common.The clinical estimates and low level of anaemia are taken care by the clinician and Iron deficiency is supplemented with Iron tablets.Unfortunetely the recent studies of sub clinical form of Iron deficiency in pregnant women during first trimester of the pregnancy has revealed significant effects on Brain development and a number of children born under this new deficiency threat have impaired speech and hearing defects.Imbalance of neural cells is found to be effected during iron deficiency prior to concencption,or during first two trimesters of the gestation. Later on the deficiency has been found to be non effective to brain development, Thus anemic mothers have to be cared before conception and all mothers should have the supplements containing Iron too during early prepgnancy.NOWwe have a test for detecting the brain development doddering early fetal development which works on the principle do air current movement from fetal brain to ear . They measured the resulting brain function using a common, non-invasive test called an auditory brainstem response analysis, or ABR. Stages of Fetal Brain Development Mothers low level of Iron may cause anemeia,as such clinicians advise supplements but in this case even sub clinical level known to cause anemia may too cause the deficiency syndrome in the fetus's this is abeyound anemia search which is nee ded .The subclinical iron deficiency is shown by 35-58% WOMEN WHO are not regarded as anemaeic.The child breaing women hav more deficiency score,one among every five suffers from the iron deficiency. The iron defieciency is related to slow gowth of the babies and they do show brain development defects.The ceels who make the brian during early embryonic development are effected by iron deficiency. critical period begins in the weeks prior to conception and extends through the first trimester to the onset of the second trimester.( Monique ho,2011,URMC PRESS NOT,2011)EARLY days of foetus were critical periods of gestation when the developing central nervous system was most vulnerable. They measured the resulting brain function using a common, non-invasive test called an auditory brainstem response analysis, or ABR.The placenta can minimize the impact of the mother's deficiency on the baby.Is it because of it that deficiency is exhibited during early trmister brain development phases and the later,or some mechanism helps plaventa to care for it needs research.The timing of the deficiency is more important than the important than the degree of deficiency.So a regime of iron supplementation right during the adolescence is necessary,especially near menorchy and later menusturation. Cnemotherapy and germ cell defects The lack of iron sets off an imbalance of neural procuresor cells.Chemotheraph for any cancer affect germ (sex) cells as well and thus a potential cause if infertility and mutations which may impair fertility or cause defects and disorders in the fertility.It has been observed that chemotherapy causes more infertile womenman than man s women has a germ cell pool fixed at birth where the speramatogonis male germ cell pool varies and is renewable enrgy sources.Is THIS THE reason of male potency through out life and even old age than the women whose potency to produce oocyte after menopause reduces and chances of a baby birth minimize if not seize.Is ths the resean of more wives allowed per man than more man for a single women which brings mental instability and distress,and a loe inellegence quotio.However more esearch is eeded to prove it .The cancer causes alteration of P63 and p63 protein percurcers in the cells thus making them more prone to cancer.P63 is regarded as the precursor of the whole family of cells both stem and germ cells The DNA Damage in Oocytes induces a Switch of the Quality Control Factor TAp63a from Dimer to Tetramer(,Deutsch et al., 2011) This is the possible mechanism of demage to germ cell too under chemotherapyin women and maals . .



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